Welcome to Agrawal Lab
Agrawal lab studies how environmental stressors and abused drugs affect epigenome and transcriptome in the brain leading to subsequent changes in behavior. Given the public health problem posed by stressors such as social isolation and abused drugs it is important to understand molecular mechanisms responsible for these phenomena. To approach this problem we use fruit fly Drosophila melanogaster. Drosophila is a powerful, genetically tractable model organism to study complex behaviors and it is a pivotal tool to understand genetic and epigenetic mechanisms involved in various brain disorders.
About the PI
Dr. Pavan Agrawal is an Assistant Professor and DBT, India Ramalingaswami fellow at the Centre for Molecular Neurosciences, Kasturba Medical College, Manipal, MAHE, India.
As a Postdoctoral Associate, he worked at the HHMI, Janelia Research Campus, VA, USA in the lab of Dr. Ulrike Heberlein and in close collaboration with Dr. Loren Looger.
His PhD was at Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India in the lab of Dr. L. S. Shashidhara.
His work has identified both whole brain and cell-type-specific transcriptional and epigenetic changes in Drosophila using cutting-edge genomic methods. Insights gained from these approaches are combined with high-throughput quantitative behavioral assays to identify causal mechanisms in the brain that shape these behaviors.
His lab at Kasturba Medical College, Manipal, India is exploring these themes at the level of organism, whole brain and specific cell types.